Opportunity Information: Apply for PAR 23 161
The Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed) funding opportunity (PAR-23-161) is a National Institutes of Health (NIH) grant issued by the National Center for Advancing Translational Sciences (NCATS) under the broader HEAL (Helping to End Addiction Long-term) Initiative. It is framed explicitly as part of the federal response to the nationwide public health emergency related to the opioid crisis, referencing the HHS Secretarys emergency determination and its renewal due to the continued consequences of opioid misuse, addiction, and overdose. The overall intent is workforce and skills development in translational science so that investigators can more effectively contribute to the discovery and development pipeline for new medical solutions relevant to this crisis and its related health impacts.
At its core, this FOA supports early and mid-career investigators who want to expand or redirect their research trajectory by gaining new, concrete knowledge and practical skills in therapeutic development. The emphasis is on learning and career enhancement in areas tied to developing therapeutics, including drug, biologic, or device development. In other words, it is less about funding a traditional research project from start to finish and more about enabling an investigator to obtain training, mentorship, and exposure to new translational methods, platforms, or development-stage competencies that they do not currently have, with the goal that these new capabilities will strengthen and speed their future contributions to translational science and the HEAL mission.
The FOA is geared toward investigators in the early to mid stages of an academic or research career, described in the synopsis as ranging from postdoctoral fellows or associates through associate professors. That positioning signals that applicants should already have a research foundation and an emerging or established program, but are seeking a targeted period of career enhancement to acquire additional translational expertise (for example, moving from basic discovery into preclinical development, learning regulatory science concepts, developing assay validation know-how, understanding manufacturing or formulation constraints, or building capability in device prototyping and testing workflows). The award is also labeled "Clinical Trials Not Allowed," which means applications cannot propose an NIH-defined clinical trial as part of the funded activities. This generally keeps the focus on skill-building and translational development activities that precede or support clinical testing rather than conducting interventional studies in humans under this mechanism.
Eligibility is broad and includes many types of U.S.-based organizations and government entities. The opportunity lists eligible applicants such as public and private institutions of higher education, independent school districts, and a wide range of governmental units (state, county, city or township, and special district governments), as well as federally recognized Native American tribal governments and tribal organizations that are not federally recognized. It also allows nonprofits with or without 501(c)(3) status, public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), and small businesses, along with an "other" category that can cover additional qualifying organizations. The FOA also highlights a number of institution types often associated with capacity building and inclusive participation in federal research programs, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
There are important limits on foreign participation. Non-domestic (non-U.S.) entities and non-domestic foreign institutions are not eligible to apply as the primary applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant organization may include certain foreign activities, collaborations, or performance sites when they meet NIH criteria and are appropriately justified, even though the applicant institution itself must be domestic.
Administratively, this is a discretionary grant program with a funding instrument type of Grant and activity categories spanning education and health (among others). It is associated with multiple CFDA numbers (93.121, 93.213, 93.273, 93.279, 93.350, 93.846, 93.853, 93.865, 93.866), reflecting NIH program accounting across institutes and/or related assistance listings. The opportunity record shows an original closing date of July 7, 2023, and a creation date of April 19, 2023. The synopsis provided does not specify an award ceiling or expected number of awards, so those details would typically be confirmed in the full FOA text and any accompanying NIH notices or budget guidance.
Taken together, this K18 opportunity is best understood as a time-limited, focused career enhancement award designed to help promising early and mid-career researchers build new translational science competencies directly relevant to the HEAL Initiatives goals. It prioritizes expanding investigators practical capacity to move potential drugs, biologics, or devices along the development path, while explicitly excluding the conduct of clinical trials under this award mechanism.Apply for PAR 23 161
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Emergency Awards: HEAL Initiative: Translational Science Career Enhancement Awards for Early and Mid-career Investigators (K18 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.213, 93.273, 93.279, 93.350, 93.846, 93.853, 93.865, 93.866.
- This funding opportunity was created on 2023-04-19.
- Applicants must submit their applications by 2023-07-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (PAR 23 161) also looked into and applied for these:
| Funding Opportunity |
|---|
| BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional) Apply for RFA NS 23 025 Funding Number: RFA NS 23 025 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Planning Projects TargetedBCPP (R34 Clinical Trials Not Allowed) Apply for RFA NS 23 023 Funding Number: RFA NS 23 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $450,000 |
| BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed) Apply for RFA NS 23 024 Funding Number: RFA NS 23 024 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional) Apply for RFA MH 23 295 Funding Number: RFA MH 23 295 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) Apply for RFA MH 23 290 Funding Number: RFA MH 23 290 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative Partnerships to Advance INterdisciplinary (PAIN) Training in Clinical Pain Research: The HEAL PAIN Cohort Program (T90/R90 Independent Clinical Trial Not Allowed) Apply for RFA NS 24 015 Funding Number: RFA NS 24 015 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed) Apply for PAR 23 199 Funding Number: PAR 23 199 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $220,000 |
| HEAL Initiative: Toward Developing Quantitative Imaging and Other Relevant Biomarkers of Myofascial Tissues for Clinical Pain Management (R61/R33, Clinical Trial Required) Apply for RFA AT 24 003 Funding Number: RFA AT 24 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) Apply for RFA MH 24 280 Funding Number: RFA MH 24 280 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R21 Clinical Trial Not Allowed) Apply for RFA DA 24 064 Funding Number: RFA DA 24 064 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $275,000 |
| HEAL Initiative: Novel Targets for Opioid Use Disorders and Opioid Overdose (R01 Clinical Trial Not Allowed) Apply for RFA DA 24 063 Funding Number: RFA DA 24 063 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional) Apply for RFA NS 24 021 Funding Number: RFA NS 24 021 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Mitigating Health Disparities experienced by People with Disabilities caused by Ableism (R01 Clinical Trial Optional) Apply for RFA HD 24 007 Funding Number: RFA HD 24 007 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $499,999 |
| HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain Program Resource and Data Center (U24 Clinical Trial Not Allowed) Apply for RFA HD 24 012 Funding Number: RFA HD 24 012 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Coordination and Translation Center (U2C Clinical Trial Optional) Apply for RFA DA 24 069 Funding Number: RFA DA 24 069 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Methodology and Advanced Analytics Resource Center (UM1 Clinical Trial Not Allowed) Apply for RFA DA 24 068 Funding Number: RFA DA 24 068 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL INITIATIVE: Development and validation of remote or patient wearable device derived objective biosignatures or functional assessments to monitor pain for use as endpoints in clinical trials (UG3/UH3 - Clinical Trial Optional) Apply for RFA NS 24 023 Funding Number: RFA NS 24 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed) Apply for RFA EY 23 001 Funding Number: RFA EY 23 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| Health and Health Care Disparities Among Persons Living with Disabilities (R01 - Clinical Trials Optional) Apply for PAR 23 309 Funding Number: PAR 23 309 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| Career Enhancement Award to Advance the Study of Intimate Partner Violence (IPV) in the Context of Maternal Morbidity and Mortality Research (K18 Clinical Trial Not Allowed) Apply for RFA OD 24 001 Funding Number: RFA OD 24 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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