Opportunity Information: Apply for PAR 22 195
The INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Research Short Course funding opportunity (PAR-22-195) is a National Institutes of Health (NIH) Research Education Program (R25) grant that focuses on building the clinical research workforce dedicated to Down syndrome (DS). It sits under the NIH INCLUDE Project, a broader effort aimed at improving health outcomes and quality of life for people with DS by deepening understanding of DS and the medical conditions that commonly occur alongside it across the lifespan. Rather than funding a traditional research study, this FOA is designed to support structured education and training activities, specifically short-course programs that teach practical, state-of-the-art clinical research skills relevant to DS.
The core purpose is workforce development: NIH is looking for creative and innovative short courses that can train the next generation of DS clinical researchers. The training emphasis is on clinical research competencies that help investigators better characterize and study co-occurring clinical features in DS (for example, conditions that may affect cognition, heart health, immune function, sleep, metabolism, or aging-related outcomes), and that ultimately strengthen the pipeline for developing and testing interventions and treatments for health conditions experienced by individuals with DS. The FOA explicitly frames this as a way to expand and diversify the pool of well-prepared DS researchers, meaning applicants are generally expected to think intentionally about recruitment, reach, and accessibility of training to bring more people into DS-focused clinical research.
This opportunity uses the R25 activity code, which NIH reserves for research education programs that complement and enhance the training of a workforce in areas aligned with NIH’s mission. The “Independent Clinical Trial Not Allowed” designation means the award is not intended to support an applicant-led clinical trial as the primary project. In practice, the proposal should be centered on education and training infrastructure, curriculum, mentoring, and skills development rather than running a clinical trial. Training may still cover clinical trial methods and best practices as educational content, but the grant mechanism is not meant to serve as the vehicle for conducting a new independent trial.
Eligibility is broad and includes many U.S.-based organization types: state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also highlights additional eligible applicant categories that NIH is particularly interested in seeing participate, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions. Foreign organizations and foreign institutions (non-U.S. entities) are not eligible to apply, but non-domestic components of U.S. organizations may be eligible. The FOA also notes NIH policy language around “foreign components” as defined in the NIH Grants Policy Statement, signaling that applicants should pay attention to NIH rules if any part of the educational effort involves resources, performance sites, faculty, or activities outside the U.S.
Administratively, it is a discretionary grant program run by NIH, categorized under education, health, income security, and social services. The CFDA numbers listed in the notice indicate that multiple NIH institutes and centers may be participating or that the funding aligns with several NIH program areas. The opportunity was created on 2022-10-03, and the original closing date listed is 2025-09-07. An award ceiling is not specified in the provided listing, and the expected number of awards is also not specified, so applicants typically need to consult the full FOA text and NIH budget guidance for allowable costs, budget structure, and any institute-specific limits or expectations.
Overall, PAR-22-195 is best understood as NIH inviting organizations to build high-quality, short-format training programs that can quickly upskill trainees, early-career investigators, and other learners into competent DS clinical researchers. The expected end result is not just a one-time course, but a measurable contribution to a stronger, more diverse DS clinical research workforce capable of studying co-occurring conditions across the lifespan and accelerating progress toward better care and new treatments for people with Down syndrome.Apply for PAR 22 195
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Research Short Course (R25 Independent Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.307, 93.398, 93.837, 93.838, 93.839, 93.840, 93.853, 93.865, 93.866, 93.867, 93.989.
- This funding opportunity was created on 2022-10-03.
- Applicants must submit their applications by 2025-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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