Opportunity Information: Apply for SP 22 004
The Strategic Prevention Framework-Partnerships for Success (SPF-PFS) grant is a discretionary funding opportunity from the U.S. Department of Health and Human Services, administered through the Substance Abuse and Mental Health Services Administration (SAMHSA). Its core aim is to reduce the onset and escalation of substance misuse and the related harms that come with it, while also strengthening mental health promotion at the state and community level. Rather than focusing on treatment after problems have already become severe, this program emphasizes prevention and early intervention strategies that can reduce risk and build protective factors across communities.
A central feature of SPF-PFS is that it is built around the Strategic Prevention Framework (SPF), which is a community engagement and planning model rooted in public health practice. In practical terms, that means funded efforts are expected to be data-driven, organized, and based on evidence. Grantees are meant to use reliable information, including local, state, and national substance use and public health data, to understand what is happening in their communities, identify which problems are most urgent, and decide where prevention work can have the strongest impact. The program also stresses implementation of evidence-based services, meaning prevention approaches that have credible research support rather than informal or untested activities.
The opportunity specifically targets high-risk, underserved communities and at-risk sub-populations. Applicants and eventual recipients are expected to use data to identify which groups are being disproportionately affected or are more likely to experience harm, and then tailor prevention strategies accordingly. The grant recognizes that substance use trends and drivers differ widely across locations, so local context matters. SPF-PFS supports work that strengthens prevention capacity, meaning it helps states and communities improve their ability to plan, coordinate, deliver, and sustain effective prevention services over time, not just run short-term campaigns.
Substance use concerns named within the program’s scope include underage drinking, marijuana, tobacco and nicotine products (including electronic cigarettes), and highly harmful opioids and heroin. Grantees are expected to select prevention priorities based on the best available data and then design and implement strategies that prevent misuse while promoting mental health and overall well-being among both youth and adults. The emphasis is not only on reducing substance use itself, but also on reducing the related negative outcomes and improving community health conditions that influence risk, such as access to supportive services, community norms, and protective environments.
From an administrative standpoint, this opportunity is listed as Funding Opportunity Number SP 22 004 under CFDA (now Assistance Listing) 93.243, categorized under Health. The funding instrument is a grant, with an award ceiling of $1,250,000, and SAMHSA anticipated making about 12 awards under this announcement. The opportunity was created on April 12, 2022, with an original closing date of June 13, 2022. Eligibility is listed broadly as "Others," with additional eligibility details referenced in the full announcement text, suggesting that applicants may include certain non-standard or specifically defined entities beyond the most common categories.
Overall, SPF-PFS is designed to help communities move from general concern about substance misuse to a structured, measurable prevention approach: identify priority problems using data, focus on underserved and high-risk groups, apply evidence-based prevention strategies, and build lasting prevention infrastructure that supports healthier outcomes across the lifespan.Apply for SP 22 004
- The Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Strategic Prevention Framework-Partnerships for Success" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
- This funding opportunity was created on Apr 12, 2022.
- Applicants must submit their applications by Jun 13, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,250,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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| Addressing Dementia in Indian Country: Models of Care Apply for HHS 2022 IHS ALZ 0001 Funding Number: HHS 2022 IHS ALZ 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Health Funding Amount: $200,000 |
| Ending the HIV/HCV Epidemics in Indian Country Apply for HHS 2022 IHS ETHIC 0001 Funding Number: HHS 2022 IHS ETHIC 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Health Funding Amount: $200,000 |
| Demonstrating Effective Policies To Promote Black Youth Mental Health Apply for MP CPI 22 001 Funding Number: MP CPI 22 001 Agency: Department of Health and Human Services, Office of the Assistant Secretary for Health Category: Health Funding Amount: $400,000 |
| PEPFAR Uganda Community Grants to Combat HIV/AIDS Apply for DOS UGA SMGCG FY23 Funding Number: DOS UGA SMGCG FY23 Agency: Department of State, U.S. Mission to Uganda Category: Health Funding Amount: $15,000 |
| Comprehensive Child Centered Care and Services (C4S) Activity Apply for RFI62122OH002 Funding Number: RFI62122OH002 Agency: Agency for International Development, Tanzania USAID-Dar es Salaam Category: Health Funding Amount: $20,000,000 |
| USAID Enhanced HIV Services for Epidemic Control Apply for 72051722RFA00001 Funding Number: 72051722RFA00001 Agency: Agency for International Development, Dominican Republic USAID-Santo Domingo Category: Health Funding Amount: $19,098,000 |
| Preventing Maternal Mortality: Supporting Maternal Mortality Review Committees Apply for CDC RFA DP22 2211 Funding Number: CDC RFA DP22 2211 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $600,000 |
| Increasing Uptake of Long-Acting Injectable Antiretrovirals Among People with HIV Apply for HRSA 22 155 Funding Number: HRSA 22 155 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $1,500,000 |
| Cooperative Agreement for the Center of Excellence for Building Capacity in Nursing Facilities to Care for Residents with Behavioral Health Conditions Apply for SM 22 011 Funding Number: SM 22 011 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $4,962,223 |
| Delta Region Rural Health Workforce Training Program Apply for HRSA 22 164 Funding Number: HRSA 22 164 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $550,000 |
| Sober Truth on Preventing Underage Drinking Act Grants Apply for SP 22 006 Funding Number: SP 22 006 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $50,000 |
| Rural Behavioral Health Workforce Centers – Northern Border Region Apply for HRSA 22 163 Funding Number: HRSA 22 163 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $625,000 |
| National Center for Disability, Equity, and Intersectionality Apply for HHS 2022 ACL AOD NCDE 0083 Funding Number: HHS 2022 ACL AOD NCDE 0083 Agency: Department of Health and Human Services, Administration for Community Living Category: Health Funding Amount: $500,000 |
| Tribal Opioid Response Grants Apply for TI 22 006 Funding Number: TI 22 006 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $1,925,000 |
| Tribal Public Health Capacity Building and Quality Improvement Umbrella Cooperative Agreement Apply for CDC RFA OT18 18030501SUPP22 Funding Number: CDC RFA OT18 18030501SUPP22 Agency: Department of Health and Human Services, Centers for Disease Control - OSTLTS Category: Health Funding Amount: Case Dependent |
| Strengthening Public Health Systems and Services through National Partnerships to Improve and Protect the Nation's Health Apply for CDC RFA OT18 18020501SUPP22 Funding Number: CDC RFA OT18 18020501SUPP22 Agency: Department of Health and Human Services, Centers for Disease Control - OSTLTS Category: Health Funding Amount: Case Dependent |
| Improving Maternal Health through Addressing Endometriosis, Fibroids, and/or Polycystic Ovary Syndrome Apply for WH AST 22 001 Funding Number: WH AST 22 001 Agency: Department of Health and Human Services, Office of the Assistant Secretary for Health Category: Health Funding Amount: $300,000 |
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